My instincts were right with this one. Once Bitten, Twice Shy by Jennifer Rardin stood out from all the other urban fantasies right from the start. For me, it was a great and long-overdue introduction to the urban fantasy genre.
Rardin invented a great deal of vampire mythology, but she saw fit to keep all the traditional aspects as well. One can fend a vampire off with a cross, and holy water will cause even the most deadly vampire to back off.